Shicobal P 86d6dc7What should I know about hydroxyzine compared with Benadryl, Xanax, Lexapro, or Zoloft? Hydroxyzine belongs to a group of drugs called antihistamines. It s prescribed to: treat anxiety; Sertraline (Zoloft); Thioridazine (Mellaril); Thiothixene (Navane) Hydroxyzine (Vistaril); Meclizine (Antivert); Nizatidine (Axid) Vistaril (hydroxyzine) is an antihistamine, or allergy medication, that...